Marinate the chicken in buttermilk for at least 1 hour.
Prepare a dredging station with three bowls: flour mixture, beaten eggs, and breadcrumbs.
In a bowl, mix the flour, paprika, garlic powder, onion powder, salt, and black pepper.
Dredge each chicken strip in the flour mixture, then dip in the egg, and finally coat with panko breadcrumbs.
Spray the air fryer basket with cooking spray and preheat the air fryer to 400°F (200°C).
Arrange the battered chicken tenders in a single layer in the air fryer basket.
Spray the tops of the chicken tenders with cooking spray before air frying.
Air fry the chicken for 10-12 minutes, turning halfway through, until golden brown.
Check for doneness with a meat thermometer, aiming for 165°F (75°C).
Let the tenders rest for a few minutes before serving.